Oxidative stability of fish oil dietary supplements and their cytotoxic effect on cultured human keratinocytes

Commercially available fish oil supplements (FOS) are rich in n-3 polyunsaturated fatty acids (n-3 PUFAs) and have been prescribed as complementary therapy to reduce symptoms many inflammatory skin diseases. The objective of this study was assess the PUFAs content, oxidative stability investigate inhibitory effects on immortalized human keratinocytes (HaCaT) cell growth FOS commercialized Brazil. composition, analyzed by gas chromatography, similar for all capsules (comprising up 30% underwent no significant alteration during storage period (9, 12, 18 24 months). Primary (peroxide), secondary (anisidine), total oxidation products levels only two exceeded maximum established international quality standards, however, it is recommendable that should not exceed months at ambient temperature. Some exhibited dose-dependent HaCaT proliferation.